TCD17620

A Phase 1/2, open-label, first-in-human, dose escalation, and dose expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR445877 administered as monotherapy in adults with advanced solid tumors.

  • NKI code: M22TCD
  • Company code: TCD17620
  • Code clinicaltrials.gov: NCT05584670

Principal investigator

Dr. M. van Dongen

Medication

SAR445877 (PD1-IL15 antibody)

Summary

This study will look at how safe the new drug is SAR445877 and how well it works. SAR445877 is tested in different strengths in patients with advanced cancer. The main objective of the dose escalation part (Part 1) of this study is to determine the best dose of SAR445877 that is safe and well tolerated. The study also tests how the body processes SAR445877. The dose expansion part (Part 2) of the study will determine the safety and preliminary efficacy of SAR445877.

Read more on clinicaltrials.gov

Notes

  • Cohort A1/A1: NSCLC – closed
  • Cohort C1/C2: Gastric/GEAC – open

 

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